There has been tremendous progress over the past decade in understanding the neurobiology of pain and CNS conditions. An explosion of cutting-edge methodologies and tools are emerging that more closely link preclinical and clinical development.
Bridging the gap from bench to bedside will require new and innovative ways of thinking, an increased investment in resources, and a collaborative approach among industry experts.
MD Biosciences research collaborative is bringing together some of the most innovative minds for a 2-day event. These experts will discuss how translational models, biomarkers and other clinically relevant endpoints, and interactions with clinical physicians will bring new approaches that aid in successful development of pain therapies.
WELCOME AND MDB NEURO OVERVIEW Sigal Meilin PhD | CSO, MD Biosciences. Israel
THE HISTORY OF GÖTTINGEN MINIPIGS Peter Vestbjerg | Head of International Sales, Ellegaard Gottingen Minipigs. Denmark
THE USE OF GÖTTINGEN MINIPIGS IN BIOMEDICAL RESEARCH Andres Eskjær Jensen | Scientific team, Ellegaard Gottingen Minipigs. Denmark
10:00 AM coffee break
10:45 AM - 12:15 pm
Session I: THE USE OF PIGS IN PAIN RESEARCH: FOCUS ON CHRONIC PAIN
Chair: Dr Sigal Meilin, CSO MD Biosciences
THE ROLE OF PORCINE MODELS IN TRANSLATIONAL PAIN RESEARCH, WITH A FOCUS ON NEUROPATHIC MODELS Suzan Meijs, PhD | Assistant Professor, Center for Neuroplasticity and Pain (CNAP), Dept. Of Health Science and Technology, The Faculty of Medicine, Aalborg University. Denmark
ELECTROPHYSIOLOGICAL AND TRANSCRIPTIONAL DISSECTION OF PIG SOMATOSENSORY NEURONS Hans Jürgen Solinski, PhD | Department of Experimental Pain Research Mannheim Center for Translational Neuroscience, Ruprecht-Karls- University. Heidelberg, Germany
PNT MODEL FOR NEUROPATHIC PAIN IN THE PIGS AND SKIN BIOMARKERS Avital Schauder, PhD | Head of Histology laboratory, MD Biosciences. Israel
12:15 pm lunch
1:15 - 2:45 pm
Session II: POST-SURGICAL PAIN-TRANSLATIONAL RESEARCH
Chair: Prof. Esther Pogatzki-Zahns
ADVANCES IN TRANSLATIONAL PAIN RESEARCH RELATED TO ACUTE AND CHRONIC PAIN AFTER SURGERY: PARALLEL EXPERIMENTS IN SPECIFIC RODENT PAIN MODELS, HUMANS AND PATIENTS Esther Pogatzki-Zahn and Dr. Daniel Segelcke, Univ. Prof. Dr. Med. | Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital. Muenster, Germany
THE ANALGESIC ACTIVITY OF ABOBOTULINUMTOXIN A IN POSTOPERATIVE PAIN MODELS IN THE PIG Mikhail Kalinichev, PhD | Head of Translational Science, Addex Therapeutics. Switzerland
THE HTX-001 STORY Sigal Meilin, PhD | CSO, MD Biosciences. Israel
2:45 pm coffee break
3:30 - 5:00 pm
Session III: PAINFUL NEUROMA CLINICAL AND PRECLINICAL ASPECTS
Chair: Prof. Shimon Rochind
NEUROMAS PATHOPHYSIOLOGIA NERVE REGENERATION AND ANIMAL MODELS Mark A. Mahan, MD, FAANS | Associate Professor Department of Neurosurgery, University of Utah. USA
PAINFUL NEUROMA FROM THE CLINIC TO THE ANIMALS, TRYING TO ANSWER A CLINICAL QUESTION USING AN ANIMAL MODEL Amir Arami, MD | Head of the Hand surgery and Microsurgery department at Sheba Medical Center. Israel
REVIVING MATRIX FOR RECONSTRUCTION OF TRAUMATIC INJURIES TO THE PERIPHERAL NERVES AND SPINAL CORD Shimon Rochkind Director, Prof. Dr. MD/PhD | Tel Aviv University, Head, Microsurgical Center for Peripheral Nerve Reconstruction, Assuta Medical Center, Israel
5:00 - 8:00 pm Social event and dinner
March 9, 2023
7:15 am meet for bus transport
8:30 - 9:00 am
CNS RESEARCH FACILITY TOUR
David (Didi) Castel, DVM | Chief Veterinarian Officer, MD Biosciences Avital Schauder, PhD | Head of Histopathology Department, MD Biosciences Sigal Meilin, PhD | CSO, MD Biosciences
9:00 am COFFEE BREAK
9:45 - 10:45 AM
Session IV: RESOLVING PAIN - DIFFERENT APPROACH TO PAIN THERAPY
Chair: Matan Nachliely PhD, MD Biosciences
ADS012, A NOVEL NON-COLONIZING ORALLY DELIVERED SINGLE STRAIN LIVE BIOTHERAPEUTIC PRODUCT (SS-LBP) FOR THE TREATMENT OF NEUROINFLAMMATORY DISEASES Laurent Chesnel, PhD | VP Research and Development, AdisoTherapeutics. USA
EXERCISE PREHABILITATION AND IMMUNE REGULATION IN NEUROPATHIC PAIN Peter M Grace, PhD | Associate Professor and Chair ad interim, Department of Symptom Research Laboratories of Neuroimmunology, MD Anderson Cancer Center. Houston, TX, USA
10:45 am coffee break
11:15 am - 12:15 pm
Session V: VIEW ON PAIN BIOMARKERS
Chair: Avital Schauder, MD Biosciences Israel
IN VIVO ELECTROPHYSIOLOGY A BIOMARKER FOR PAIN Yoav Shulman, PhD | Neurophysiology, MD Biosciences. Israel
GABAPENTIN TREATMENT ATTENUATES INFLAMMATORY MARKERS IN STZ INDUCED NEUROPATHIC PAIN Sigal Meilin, PhD | CSO, MD Biosciences. Israel
CLOSING REMARKS Boxed lunch available to go
In the heart of the beautiful Mediterranean, Israel has a thriving life science and MedTech sector. Compared with the rest of the world, Israel spends the highest percentage of GDP on research and development. Make it a long weekend and enjoy a sunny start to spring with temperatures in the high 60s, low 70s in early March.
Travel and Lodging
Ayalon Institute museum, Rehovot Science Park
The historic Ayalon Institute Museum is located at 1 David Fikes Str., in the Rehovot Science Science Park.
A bus to the conference center will wait in front of the hotel at 7:45 am for the hotel guests and participants that are arriving by train. At the end of the day (approx. 20:00) a bus will return the participants to the hotel/train station.
Leonardo Boutique Rehovot Hotel
We have arranged a special rate at the Leonardo Boutique. Room rates for the conference are 580 NIS (single) or 660 NIS (double). In order to receive the conference rate, rooms must be booked by February 8, 2023. To reserve a conference room, please email [email protected] with the following details: One night, March 08 Leonardo Boutique Rehovot Hotel Order number: 116031.
A bus to the Ayalon Institute Museum will wait in front of the hotel at 7:45 am for the hotel guests and participants that are arriving by train. At the end of the day (approx. 20:00) a bus will return the participants to the hotel/train station.